Standard
Orofacial clefts
THADA · rs7590268
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Orofacial clefts compared to the general population. (GWAS Catalog, Nat Genet 2012, PMID:22863734)
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Orofacial clefts. (GWAS Catalog, Nat Genet 2012, PMID:22863734)
T/T
Published research associates this genotype with typical/baseline likelihood of Orofacial clefts — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2012, PMID:22863734)
Source
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
Ludwig KU,
Mangold E,
Herms S,
Nowak S,
Reutter H,
Paul A,
Becker J,
Herberz R,
AlChawa T,
Nasser E,
Böhmer AC,
Mattheisen M
and 27 more — show all
Alblas MA,
Barth S,
Kluck N,
Lauster C,
Braumann B,
Reich RH,
Hemprich A,
Pötzsch S,
Blaumeiser B,
Daratsianos N,
Kreusch T,
Murray JC,
Marazita ML,
Ruczinski I,
Scott AF,
Beaty TH,
Kramer FJ,
Wienker TF,
Steegers-Theunissen RP,
Rubini M,
Mossey PA,
Hoffmann P,
Lange C,
Cichon S,
Propping P,
Knapp M,
Nöthen MM
Nature genetics · 2012 · PMID 22863734
Questions about rs7590268
What is rs7590268?
rs7590268 is a single position in the genome, in or near the THADA gene. Published research associates it with orofacial clefts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7590268 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7590268 come from?
GWAS Catalog, Nat Genet 2012, PMID:22863734. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants