0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 3,860 European, African, Admixed American, East Asian, South Asian or unknown ancestry cases, 38,942 European, African, Admixed American, East Asian, South Asian or unknown ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.176 higher (95% confidence interval 0.12-0.23); p = 8 × 10−11.
How common The T allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 2, band 2p22.2 — in an intron of STRN.
What each result means
C/CNo copy of the version the research linked to Hypertrophic cardiomyopathy (sarcomere-negative). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hypertrophic cardiomyopathy (sarcomere-negative). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hypertrophic cardiomyopathy (sarcomere-negative). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39966646 · open access
Questions about rs7588378
What is rs7588378?
rs7588378 is a single position in the genome, in or near the STRN gene. Published research associates it with hypertrophic cardiomyopathy (sarcomere-negative). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7588378 linked to?
On MyGeneLog this position is linked to Hypertrophic Cardiomyopathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs7588378 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7588378 come from?
GWAS Catalog, Nature genetics 2025, PMID:39966646. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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