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Sex hormone-binding globulin levels

near ONECUT2 · rs75880130

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 310,323 European ancestry individuals, 5,523 African ancestry individuals, 6,638 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0285 lower (95% confidence interval 0.02-0.037); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 18, band 18q21.31 — between genes, 4.8 kb from ONECUT2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Sex hormone-binding globulin levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sex hormone-binding globulin levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sex hormone-binding globulin levels compared to the general population.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs75880130

What is rs75880130?

rs75880130 is a single position in the genome, in or near the near ONECUT2 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs75880130 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75880130 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sex hormone-binding globulin levels (rs75880130). MyGeneLog™. https://www.mygenelog.com/variants/rs75880130

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