4 4732326122224Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity2Meta AI6Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others24Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied Up to 2,916 European ancestry Type 1 Diabetes cases with nephropathy, 3,315 European ancestry Type 1 Diabetes cases without nephropathy; replicated in Up to 1,493 European ancestry Type 1 Diabetes cases with nephropathy, 3,191 European ancestry Type 1 Diabetes cases without nephropathy.
The effect
Each copy of the C allele carried 1.29 times the odds of Type 1 diabetes nephropathy (95% confidence interval 1.17-1.42); p = 3 × 10−7.
How common The C allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 2, band 2q11.2 — in an intron of AFF3.
What each result means
C/CTwo copies of the version the research linked to Type 1 diabetes nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 1 diabetes nephropathy. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 1 diabetes nephropathy. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs7583877
What is rs7583877?
rs7583877 is a single position in the genome, in or near the AFF3 gene. Published research associates it with type 1 diabetes nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7583877 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs7583877?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs7583877 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7583877 come from?
GWAS Catalog, PLoS Genet 2012, PMID:23028342. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4732326122224Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity2Meta AI6Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others24Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes nephropathy (rs7583877). MyGeneLog™. https://www.mygenelog.com/variants/rs7583877