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Who was studied 650,000 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.018 higher (95% confidence interval 0.012-0.024); p = 3 × 10−10.
How common The G allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 2, band 2q22.2 — in an intron of LRP1B.
What each result means
A/ANo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs7583748 is a single position in the genome, in or near the LRP1B gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7583748 linked to?
On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.
Does having rs7583748 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7583748 come from?
GWAS Catalog, Nature genetics 2024, PMID:39375568. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs7583748). MyGeneLog™. https://www.mygenelog.com/variants/rs7583748