Sensitive

Prostate cancer

IRS2 · rs75823044

Where this position leads

What the study found

Who was studied 5,454 African American cases, 474 West African cases, 4,274 African American and African ancestry cases, 6,328 African American controls, 458 West African controls, 4,024 African American and African ancestry controls.

The effect Each copy of the T allele carried 1.55 times the odds of Prostate cancer (95% confidence interval 1.37-1.76); p = 6 × 10⁻¹².

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 13, band 13q34 — between genes, 19.8 kb from LINC00676.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Prostate cancer — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate cancer.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate cancer compared to the general population.

Source

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry

Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB

and 77 more — show all

Stanford JL, Zheng W, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, Berndt SI, Huff CD, Wang Z, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Sellers TA, Yamoah K, Murphy AB, Crawford DC, Gapstur SM, Bush WS, Aldrich MC, Cussenot O, Petrovics G, Cullen J, Neslund-Dudas C, Stern MC, Jarai ZK, Govindasami K, Chokkalingam AP, Hsing AW, Goodman PJ, Hoffmann T, Drake BF, Hu JJ, Clark PE, Van Den Eeden SK, Blanchet P, Fowke JH, Casey G, Hennis AJM, Han Y, Lubwama A, Thompson IM Jr, Leach R, Easton DF, Schumacher F, Van den Berg DJ, Gundell SM, Stram A, Wan P, Xia L, Pooler LC, Mohler JL, Fontham ETH, Smith GJ, Taylor JA, Srivastava S, Eeles RA, Carpten J, Kibel AS, Multigner L, Parent ME, Menegaux F, Cancel-Tassin G, Klein EA, Brureau L, Stram DO, Watya S, Chanock SJ, Witte JS, Blot WJ, Henderson BE, Haiman CA

PRACTICAL/ELLIPSE Consortium

Journal of the National Cancer Institute · 2017 · PMID 29117387 · open access

Questions about rs75823044

What is rs75823044?

rs75823044 is a single position in the genome, in or near the IRS2 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75823044 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs75823044 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75823044 come from?

GWAS Catalog, J Natl Cancer Inst 2017, PMID:29117387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants