GBA · rs75822236
Where this position leads
Condition: Intracranial Aneurysm
What the study found
Who was studied 250 Korean ancestry cases, 296 Korean ancestry controls.
The effect Each copy of the T allele carried 161.40 times the odds of Intracranial aneurysm (95% confidence interval 53.86-483.6); p = 1 × 10−19.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 1, band 1q22 — a missense change in GBA1.
What ClinVar records
Classification
Pathogenic/Likely pathogenic for Gaucher disease type I, Gaucher disease, Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome, Gaucher disease type II, Gaucher disease type III and 4 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 22 submitters), last evaluated 2026-08-27.
ClinVar record 4311 NM_000157.4(GBA1):c.1604G>A (p.Arg535His)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs75822236 is a single position in the genome, in or near the GBA gene. Published research associates it with intracranial aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Intracranial Aneurysm. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Journal of clinical medicine 2019, PMID:30823506. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Intracranial aneurysm (rs75822236). MyGeneLog™. https://www.mygenelog.com/variants/rs75822236