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Chronotype

PER2 · rs75804782

Where this position leads

Condition: Sleep and Circadian Rhythm

rs75804782 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs75804782 rs75804782 PER2

What the study found

Who was studied 127,898 British individuals; replicated in 89,283 individuals.

The effect Each copy of the T allele shifted the measure 0.03 higher (95% confidence interval 0.018-0.042); p = 1 × 10−14.

How common The T allele had a frequency of about 88% in the people studied.

Where it sits Chromosome 2, band 2q37.3 — between genes, 5.2 kb from RNU6-234P.

What each result means

C/C No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, Roenneberg T, Wilson JF
and 15 more — show all
Del Greco F, Hicks AA, Shin C, Yun CH, Lee SK, Metspalu A, Byrne EM, Gehrman PR, Tiemeier H, Allebrandt KV, Freathy RM, Murray A, Hinds DA, Frayling TM, Weedon MN
PLoS genetics · 2016 · PMID 27494321 · open access

Questions about rs75804782

What is rs75804782?

rs75804782 is a single position in the genome, in or near the PER2 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75804782 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs75804782 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75804782 come from?

GWAS Catalog, PLoS Genet 2016, PMID:27494321. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronotype (rs75804782). MyGeneLog™. https://www.mygenelog.com/variants/rs75804782

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