Who was studied 4,511 European ancestry cases, 227,260 European ancestry controls, 1,786 East Asian ancestry cases, 80,975 East Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.194 higher (95% confidence interval 0.13-0.26); p = 1 × 10−9.
Where it sits Chromosome 2, band 2p25.1 — in an intron of GREB1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Endometriosis — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Endometriosis.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Endometriosis compared to the general population.
rs7580473 is a single position in the genome, in or near the GREB1 gene. Published research associates it with endometriosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7580473 linked to?
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
Does having rs7580473 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7580473 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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