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Endometriosis

GPNMB · rs75801644

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

What the study found

Who was studied 171 European ancestry cases, 2,934 European ancestry controls.

The effect Each copy of the A allele carried 3.88 times the odds of Endometriosis (95% confidence interval 2.44-6.176); p = 8 × 10⁻¹⁰.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 7, band 7p15.3 — a missense change in GPNMB.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Endometriosis compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Endometriosis.

G/G Published research associates this genotype with typical/baseline likelihood of Endometriosis — no copies of the reported risk allele.

Source

New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study

Sobalska-Kwapis M, Smolarz B, Słomka M, Szaflik T, Kępka E, Kulig B, Siewierska-Górska A, Polak G, Romanowicz H, Strapagiel D, Szyłło K

European journal of obstetrics, gynecology, and reproductive biology · 2017 · PMID 28881265

Questions about rs75801644

What is rs75801644?

rs75801644 is a single position in the genome, in or near the GPNMB gene. Published research associates it with endometriosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75801644 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs75801644 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75801644 come from?

GWAS Catalog, Eur J Obstet Gynecol Reprod Biol 2017, PMID:28881265. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Endometriosis (rs75801644). MyGeneLog™. https://www.mygenelog.com/variants/rs75801644

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