Sensitive

Poor prognosis in Crohn's disease

IGFBP1 · rs75764599

Where this position leads

Condition: Crohn's Disease

rs75764599 Condition: Crohn's Disease Crohn's Disease Condition rs75764599 rs75764599 IGFBP1

What the study found

Who was studied 1,762 Northern European ancestry poor prognosis cases, 972 Northern European ancestry good prognosis controls..

The effect Each copy of the A allele carried 3.02 times the odds of Poor prognosis in Crohn's disease (95% confidence interval 2.04-4.49); p = 4 × 10−8.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 7, band 7p12.3 — between genes, 0.3 kb from CCDC201.

What each result means

A/A Two copies of the version the research linked to Poor prognosis in Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Poor prognosis in Crohn's disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Poor prognosis in Crohn's disease. This is the starting point the study compared everyone against.
Source

Questions about rs75764599

What is rs75764599?

rs75764599 is a single position in the genome, in or near the IGFBP1 gene. Published research associates it with poor prognosis in crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75764599 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs75764599 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75764599 come from?

GWAS Catalog, Nat Genet 2017, PMID:28067912. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Poor prognosis in Crohn's disease (rs75764599). MyGeneLog™. https://www.mygenelog.com/variants/rs75764599

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