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Who was studied 435 Turkish uveitis cases, 780 Turkish without uveitis cases, 1,278 Turkish controls; replicated in 355 Turkish uveitis cases, 483 Turkish without uveitis cases, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls.
The effect
Each copy of the A allele carried 1.27 times the odds of Behcet's disease (95% confidence interval 1.17-1.37); p = 1 × 10−9.
How common The A allele had a frequency of about 42% in the people studied.
Where it sits Chromosome 2, band 2q32.3 — in an intron of STAT4.
What each result means
A/ATwo copies of the version the research linked to Behcet's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Behcet's disease. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Behcet's disease. This is the starting point the study compared everyone against.
Nature genetics · 2013 · PMID 23291587 · open access
Questions about rs7574070
What is rs7574070?
rs7574070 is a single position in the genome, in or near the STAT4 gene. Published research associates it with behcet's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7574070 linked to?
On MyGeneLog this position is linked to Behcet's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7574070 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7574070 come from?
GWAS Catalog, Nature genetics 2013, PMID:23291587. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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