Standard

Systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test)

DOCK4 · rs757194

Where this position leads

Condition: Blood Pressure

What the study found

Who was studied 29,626 African American or Afro-Caribbean, African ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10⁻⁹.

Where it sits Chromosome 7, band 7q31.1 — in an intron of DOCK4.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test).

G/G Published research associates this genotype with typical/baseline likelihood of Systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test) — no copies of the reported risk allele.

Source

Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations

Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison JL, Schwander K, Westerman K, Kho M, Kraja AT, de Vries PS

and 137 more — show all

Ammous F, Aschard H, Bartz TM, Do A, Dupont CT, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Hikino K, Huang Z, Lefevre C, Lyytikäinen LP, Milaneschi Y, Nardone GG, Santin A, Schmidt H, Shen B, Sofer T, Sun Q, Tan YA, Tang J, Thériault S, van der Most PJ, Ware EB, Weiss S, Xing WY, Yu C, Zhao W, Ansari MAY, Anugu P, Attia JR, Bazzano LA, Bis JC, Breyer M, Cade B, Chen G, Collins S, Corley J, Davies G, Dörr M, Du J, Edwards TL, Faquih T, Faul JD, Fohner AE, Fretts AM, Gangireddy S, Gepner A, Graff M, Hofer E, Homuth G, Hood MM, Jie X, Kähönen M, Kardia SLR, Karvonen-Gutierrez CA, Launer LJ, Levy D, Maheshwari M, Martin LW, Matsuda K, McNeil JJ, Nolte IM, Okochi T, Raffield LM, Raitakari OT, Risch L, Risch M, Roux AD, Ruiz-Narvaez EA, Russ TC, Saito T, Schreiner PJ, Scott RJ, Shikany J, Smith JA, Snieder H, Spedicati B, Tai ES, Taylor AM, Taylor KD, Tesolin P, van Dam RM, Wang R, Wenbin W, Xie T, Yao J, Young KL, Zhang R, Zonderman AB, Concas MP, Conen D, Cox SR, Evans MK, Fox ER, de Las Fuentes L, Giri A, Girotto G, Grabe HJ, Gu C, Gudnason V, Harlow SD, Holliday E, Jost JB, Lacaze P, Lee S, Lehtimäki T, Li C, Liu CT, Morrison AC, North KE, Penninx BWJH, Peyser PA, Province MM, Psaty BM, Redline S, Rosendaal FR, Rotimi CN, Rotter JI, Schmidt R, Sim X, Terao C, Weir DR, Zhu X, Franceschini N, O'Connell JR, Jaquish CE, Wang H, Manning A, Munroe PB, Rao DC, Chen H, Gauderman WJ, Bierut LJ, Winkler TW, Fornage M

Biobank Japan Project · Lifelines Cohort Study,

HGG advances · 2026 · PMID 41520179 · open access

Questions about rs757194

What is rs757194?

rs757194 is a single position in the genome, in or near the DOCK4 gene. Published research associates it with systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs757194 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs757194 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs757194 come from?

GWAS Catalog, HGG advances 2026, PMID:41520179. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systolic blood pressure x depressive symptoms (dichotomous) interaction (2df test) (rs757194). MyGeneLog™. https://www.mygenelog.com/variants/rs757194

← See all variants