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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0739 lower (95% confidence interval 0.059-0.089); p = 8 × 10−24.
How common The G allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 19, band 19q13.12 — between genes, 0.6 kb from FXYD5.
What each result means
A/ANo copy of the version the research linked to ITM2A protein levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to ITM2A protein levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to ITM2A protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs756845
What is rs756845?
rs756845 is a single position in the genome, in or near the near FXYD5 gene. Published research associates it with itm2a protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs756845 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs756845 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs756845 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
ITM2A protein levels (rs756845). MyGeneLog™. https://www.mygenelog.com/variants/rs756845