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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 60,405 Hispanic or Latino individuals.
The effect
Each copy of the G allele shifted the measure 1.19 higher (95% confidence interval 0.59-1.78); p = 3 × 10−8.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 11, band 11p15.4 — a missense change in TUB.
What ClinVar records
ClassificationBenign/Likely benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-01-30.
ClinVar record 719359NM_177972.3(TUB):c.1126G>A (p.Val376Ile)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40210677 · open access
Questions about rs75594955
What is rs75594955?
rs75594955 is a single position in the genome, in or near the TUB gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs75594955 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs75594955 come from?
GWAS Catalog, Nature communications 2025, PMID:40210677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Low density lipoprotein cholesterol levels (rs75594955). MyGeneLog™. https://www.mygenelog.com/variants/rs75594955