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Waist circumference adjusted for body mass index

XKR6 · rs755856

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 186,825 British ancestry men.

The effect Each copy of the C allele shifted the measure 0.0211 lower (95% confidence interval 0.015-0.027); p = 4 × 10⁻¹¹.

Where it sits Chromosome 8, band 8p23.1 — between genes, 17 kb from XKR6.

How common each version is

CG

Korean KRGDB

C 87.8% · G 12.2%

Korean Korea4K

C 86.3% · G 13.7%

Korean Korea1K

C 86.8% · G 13.2%

Japanese ToMMo

C 86.9% · G 13.1%

Vietnamese

C 89.0% · G 10.9%

World gnomAD

C 36.7% · G 63.3%

World 1000 Genomes

C 45.3% · G 54.7%

World TOPMed

C 36.9% · G 63.1%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Waist circumference adjusted for body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Waist circumference adjusted for body mass index. That is a smaller link than two copies.

G/G No copy of the version the research linked to Waist circumference adjusted for body mass index. This is the starting point the study compared everyone against.

Source

GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer

Christakoudi S, Evangelou E, Riboli E, Tsilidis KK

Scientific reports · 2021 · PMID 34021172 · open access

Questions about rs755856

What is rs755856?

rs755856 is a single position in the genome, in or near the XKR6 gene. Published research associates it with waist circumference adjusted for body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs755856 linked to?

On MyGeneLog this position is linked to Waist Circumference. The research behind each link, and its sources, are set out on that condition page.

Does having rs755856 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs755856 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Waist circumference adjusted for body mass index (rs755856). MyGeneLog™. https://www.mygenelog.com/variants/rs755856

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