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Uterine fibroids

CTNNA2 · rs755741156

Where this position leads

Condition: Uterine Fibroids

rs755741156 Condition: Uterine Fibroids Uterine Fibroids Condition rs755741156 rs755741156 CTNNA2

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 21,024 European ancestry cases, 237,694 European ancestry controls, 14,475 East Asian ancestry cases, 65,733 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.883 higher (95% confidence interval 0.57-1.2); p = 4 × 10−8.

Where it sits Chromosome 2, band 2p12 — inside CTNNA2.

What each result means

A/A No copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs755741156

What is rs755741156?

rs755741156 is a single position in the genome, in or near the CTNNA2 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs755741156 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs755741156 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs755741156 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Uterine fibroids (rs755741156). MyGeneLog™. https://www.mygenelog.com/variants/rs755741156

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