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Total cholesterol levels

SMC6 · rs7556983

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0155 lower (95% confidence interval 0.011-0.02); p = 4 × 10−9.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 2, band 2p24.2 — in an intron of SMC6.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2019-06-14. ClinVar record 1274142 NM_001130009.3(GEN1):c.1072-283G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs7556983

What is rs7556983?

rs7556983 is a single position in the genome, in or near the SMC6 gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7556983 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7556983 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total cholesterol levels (rs7556983). MyGeneLog™. https://www.mygenelog.com/variants/rs7556983

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