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Allergic disease (asthma, hay fever or eczema)

SLC15A2 · rs75557865

Where this position leads

Condition: Asthma

rs75557865 Condition: Asthma Asthma Condition rs75557865 rs75557865 SLC15A2

What the study found

Who was studied 180,129 European ancestry cases, 180,709 European ancestry controls.

The effect Each copy of the G allele carried 1.03 times the odds of Allergic disease (asthma, hay fever or eczema) (95% confidence interval 1.02-1.04); p = 2 × 10−8.

How common The G allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 3, band 3q13.33 — in an intron of SLC15A2.

What each result means

A/A No copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Ferreira MA, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, van Dongen J, Lu Y, Rüschendorf F
and 54 more — show all
Esparza-Gordillo J, Medway CW, Mountjoy E, Burrows K, Hummel O, Grosche S, Brumpton BM, Witte JS, Hottenga JJ, Willemsen G, Zheng J, Rodríguez E, Hotze M, Franke A, Revez JA, Beesley J, Matheson MC, Dharmage SC, Bain LM, Fritsche LG, Gabrielsen ME, Balliu B, Nielsen JB, Zhou W, Hveem K, Langhammer A, Holmen OL, Løset M, Abecasis GR, Willer CJ, Arnold A, Homuth G, Schmidt CO, Thompson PJ, Martin NG, Duffy DL, Novak N, Schulz H, Karrasch S, Gieger C, Strauch K, Melles RB, Hinds DA, Hübner N, Weidinger S, Magnusson PKE, Jansen R, Jorgenson E, Lee YA, Boomsma DI, Almqvist C, Karlsson R, Koppelman GH, Paternoster L
23andMe Research Team · AAGC collaborators · BIOS consortium · LifeLines Cohort Study
Nature genetics · 2017 · PMID 29083406 · open access

Questions about rs75557865

What is rs75557865?

rs75557865 is a single position in the genome, in or near the SLC15A2 gene. Published research associates it with allergic disease (asthma, hay fever or eczema). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75557865 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs75557865 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75557865 come from?

GWAS Catalog, Nature genetics 2017, PMID:29083406. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Allergic disease (asthma, hay fever or eczema) (rs75557865). MyGeneLog™. https://www.mygenelog.com/variants/rs75557865

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