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Femoral neck width

PLCD1 · rs75495843

Where this position leads

What the study found

Who was studied 38,150 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.122 higher (95% confidence interval 0.083-0.16); p = 5 × 10⁻¹⁰.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 3, band 3p22.2 — a missense change in PLCD1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Femoral neck width compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Femoral neck width.

G/G Published research associates this genotype with typical/baseline likelihood of Femoral neck width — no copies of the reported risk allele.

Source

Femoral neck width genetic risk score is a novel independent risk factor for hip fractures

Tobias JH, Nethander M, Faber BG, Heppenstall SV, Ebsim R, Cootes T, Lindner C, Saunders FR, Gregory JS, Aspden RM, Harvey NC, Kemp JP

and 2 more — show all

Frysz M, Ohlsson C

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024 · PMID 38477772 · open access

Questions about rs75495843

What is rs75495843?

rs75495843 is a single position in the genome, in or near the PLCD1 gene. Published research associates it with femoral neck width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75495843 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs75495843 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75495843 come from?

GWAS Catalog, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024, PMID:38477772. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Femoral neck width (rs75495843). MyGeneLog™. https://www.mygenelog.com/variants/rs75495843

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