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Diverticulosis and diverticulitis (PheCode 562)

WWP2 · rs75491847

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 11,659 African American or Afro-Caribbean cases, 96,915 African American or Afro-Caribbean controls, 5,978 Hispanic or Latin American cases, 47,934 Hispanic or Latin American controls, 294 East Asian ancestry cases, 6,163 East Asian ancestry controls, 60,821 European ancestry cases, 330,833 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.06 higher (95% confidence interval 0.042-0.078); p = 2 × 10−11.

How common The C allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 16, band 16q22.1 — in an intron of WWP2.

What each result means

C/C Two copies of the version the research linked to Diverticulosis and diverticulitis (PheCode 562). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Diverticulosis and diverticulitis (PheCode 562). That is a smaller link than two copies.
T/T No copy of the version the research linked to Diverticulosis and diverticulitis (PheCode 562). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs75491847

What is rs75491847?

rs75491847 is a single position in the genome, in or near the WWP2 gene. Published research associates it with diverticulosis and diverticulitis (phecode 562). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs75491847 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75491847 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Diverticulosis and diverticulitis (PheCode 562) (rs75491847). MyGeneLog™. https://www.mygenelog.com/variants/rs75491847

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