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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 15,771 East Asian ancestry cases, 178,777 East Asian ancestry controls, 170,756 European ancestry cases, 329,443 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0135 lower (95% confidence interval 0.0088-0.0181); p = 1 × 10−8.
How common The A allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 1, band 1q25.2 — in an intron of ASTN1.
What each result means
A/ATwo copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Depression. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
JAMA psychiatry · 2021 · PMID 34586374 · open access
Questions about rs7548487
What is rs7548487?
rs7548487 is a single position in the genome, in or near the ASTN1 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7548487 linked to?
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
Does having rs7548487 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7548487 come from?
GWAS Catalog, JAMA psychiatry 2021, PMID:34586374. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license