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Who was studied 15,573 European ancestry cases, 158,408 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Type 1 diabetes (95% confidence interval 1.08-1.15); p = 2 × 10−10.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in an intron of HIPK1.
What each result means
A/ATwo copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
Genetic epidemiology · 2025 · PMID 39749473 · open access
Questions about rs7545300
What is rs7545300?
rs7545300 is a single position in the genome, in or near the HIPK1 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7545300 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs7545300 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7545300 come from?
GWAS Catalog, Genetic epidemiology 2025, PMID:39749473. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs7545300). MyGeneLog™. https://www.mygenelog.com/variants/rs7545300