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Pulmonary embolism

near RPL31P13 · rs7543981

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 622 Han Chinese ancestry cases, 8,853 Han Chinese ancestry controls; replicated in 646 Han Chinese ancestry cases, 8,810 Han Chinese ancestry controls.

The effect Each copy of the G allele carried 0.38 times the odds of Pulmonary embolism (95% confidence interval 0.27-0.54); p = 4 × 10⁻⁸.

How common The G allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 1, band 1q32.3 — between genes, 63.5 kb from RPL31P13.

What each result means

A/A No copy of the version the research linked to Pulmonary embolism. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Pulmonary embolism. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Pulmonary embolism. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population

Zhang Z, Li H, Weng H, Zhou G, Chen H, Yang G, Zhang P, Zhang X, Ji Y, Ying K, Liu B, Xu Q

and 36 more — show all

Tang Y, Zhu G, Liu Z, Xia S, Yang X, Dong L, Zhu L, Zeng M, Yuan Y, Yang Y, Zhang N, Xu X, Pang W, Zhang M, Zhang Y, Zhen K, Wang D, Lei J, Wu S, Shu S, Zhang Y, Zhang S, Gao Q, Huang Q, Deng C, Fu X, Chen G, Duan W, Wan J, Xie W, Zhang P, Wang S, Yang P, Zuo X, Zhai Z, Wang C

China pUlmonary Thromboembolism REgistry Study (CURES) investigators

BMC medicine · 2023 · PMID 37076872 · open access

Questions about rs7543981

What is rs7543981?

rs7543981 is a single position in the genome, in or near the near RPL31P13 gene. Published research associates it with pulmonary embolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7543981 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7543981 come from?

GWAS Catalog, BMC medicine 2023, PMID:37076872. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulmonary embolism (rs7543981). MyGeneLog™. https://www.mygenelog.com/variants/rs7543981

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