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Vertigo

near LINC02789 · rs7541515

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 48,072 European ancestry cases, 894,541 European ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 3 × 10−8.

Where it sits Chromosome 1, band 1q32.1 — between genes, 2.6 kb from LINC02789.

What each result means

A/A No copy of the version the research linked to Vertigo. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Vertigo. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Vertigo. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo
Skuladottir AT, Bjornsdottir G, Nawaz MS, Petersen H, Rognvaldsson S, Moore KHS, Olafsson PI, Magnusson SH, Bjornsdottir A, Sveinsson OA, Sigurdardottir GR, Saevarsdottir S
and 19 more — show all
Ivarsdottir EV, Stefansdottir L, Gunnarsson B, Muhlestein JB, Knowlton KU, Jones DA, Nadauld LD, Hartmann AM, Rujescu D, Strupp M, Walters GB, Thorgeirsson TE, Jonsdottir I, Holm H, Thorleifsson G, Gudbjartsson DF, Sulem P, Stefansson H, Stefansson K
Communications biology · 2021 · PMID 34620984 · open access

Questions about rs7541515

What is rs7541515?

rs7541515 is a single position in the genome, in or near the near LINC02789 gene. Published research associates it with vertigo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7541515 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7541515 come from?

GWAS Catalog, Communications biology 2021, PMID:34620984. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Vertigo (rs7541515). MyGeneLog™. https://www.mygenelog.com/variants/rs7541515

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