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Who was studied 4,572 European ancestry cases, 266,358 European ancestry controls; replicated in up to 956 European ancestry cases, up to 4,214 European ancestry controls, 526 cases, 528 controls.
The effect
Each copy of the A allele carried 1.25 times the odds of Basal cell carcinoma; p = 8 × 10−17.
How common The A allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 1, band 1p36.13 — in an intron of PADI6.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-07-02.
ClinVar record 704516NM_207421.4(PADI6):c.1618+204G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2015 · PMID 25855136 · open access
Questions about rs7538876
What is rs7538876?
rs7538876 is a single position in the genome, in or near the RCC2 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7538876 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs7538876 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7538876 come from?
GWAS Catalog, Nat Commun 2015, PMID:25855136. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4862123223126Reads by AI crawlersClaude6ChatGPT2Google · Gemini1Perplexity2Meta AI3Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others26Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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