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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.346 higher (95% confidence interval 0.25-0.45); p = 3 × 10−11.
Where it sits Chromosome 1, band 1p31.3 — in an intron of LEPR.
What each result means
A/ANo copy of the version the research linked to Leptin receptor levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Leptin receptor levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Leptin receptor levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2017 · PMID 28240269 · open access
Questions about rs7535099
What is rs7535099?
rs7535099 is a single position in the genome, in or near the LEPR gene. Published research associates it with leptin receptor levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7535099 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7535099 come from?
GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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