Standard

Morningness

near RNASEL · rs7534480

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 434,835 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.017 higher (95% confidence interval 0.013-0.021); p = 3 × 10⁻¹⁵.

How common The T allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 1, band 1q25.3 — between genes, 0.9 kb from RNASEL.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Morningness — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Morningness.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Morningness compared to the general population.

Source

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H

and 12 more — show all

White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D

23andMe Research Team

Nature genetics · 2019 · PMID 30804565

Questions about rs7534480

What is rs7534480?

rs7534480 is a single position in the genome, in or near the near RNASEL gene. Published research associates it with morningness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7534480 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7534480 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Morningness (rs7534480). MyGeneLog™. https://www.mygenelog.com/variants/rs7534480

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