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Weight

PDE4B · rs7527901

Where this position leads

Condition: Obesity and Body Weight

rs7527901 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs7527901 rs7527901 PDE4B

What the study found

Who was studied 360,116 European ancestry individuals, 165,419 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0125 lower (95% confidence interval 0.0092-0.0158); p = 1 × 10−13.

Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.

What each result means

C/C No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Weight. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs7527901

What is rs7527901?

rs7527901 is a single position in the genome, in or near the PDE4B gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7527901 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs7527901 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7527901 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs7527901). MyGeneLog™. https://www.mygenelog.com/variants/rs7527901

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