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Hand grip strength

CSMD1 · rs752045

Where this position leads

Condition: Hand Grip Strength

rs752045 Condition: Hand Grip Strength Hand Grip Strength Condition rs752045 rs752045 CSMD1

What the study found

Who was studied 27,581 European ancestry individuals; replicated in 6,393 individuals.

The effect Each copy of the G allele shifted the measure 0.47 kg higher (95% confidence interval 0.31-0.63); p = 5 × 10−10.

How common The G allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 8, band 8p23.2 — between genes, 26.5 kb from LOC105377797.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Hand grip strength — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hand grip strength.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hand grip strength compared to the general population.
Source
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium
Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B
and 55 more — show all
Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM
Aging cell · 2016 · PMID 27325353 · open access

Questions about rs752045

What is rs752045?

rs752045 is a single position in the genome, in or near the CSMD1 gene. Published research associates it with hand grip strength. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs752045 linked to?

On MyGeneLog this position is linked to Hand Grip Strength. The research behind each link, and its sources, are set out on that condition page.

Does having rs752045 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs752045 come from?

GWAS Catalog, Aging Cell 2016, PMID:27325353. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hand grip strength (rs752045). MyGeneLog™. https://www.mygenelog.com/variants/rs752045

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