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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 972,915 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0328 lower (95% confidence interval 0.022-0.043); p = 2 × 10−9.
How common The T allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 2, band 2p21 — between genes, 35.7 kb from LOC124907757.
What each result means
A/ANo copy of the version the research linked to Problematic alcohol use (MTAG). This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Problematic alcohol use (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Problematic alcohol use (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature neuroscience · 2020 · PMID 32451486 · open access
Questions about rs75199129
What is rs75199129?
rs75199129 is a single position in the genome, in or near the near LRPPRC gene. Published research associates it with problematic alcohol use (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs75199129 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs75199129 come from?
GWAS Catalog, Nat Neurosci 2020, PMID:32451486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Problematic alcohol use (MTAG) (rs75199129). MyGeneLog™. https://www.mygenelog.com/variants/rs75199129