RNASEH2B · rs75184679
Where this position leads
Condition: Celiac Disease
Strength of the evidence
ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars. Its strongest genetic-study result is p = 10−45, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 47,745 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.966 lower (95% confidence interval 0.83-1.1); p = 2 × 10−45.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 13, band 13q14.3 — a missense change in RNASEH2B.
What ClinVar records
Classification
Pathogenic/Likely pathogenic for Aicardi-Goutieres syndrome 2, Aicardi Goutieres syndrome, Cerebral palsy, Abnormality of the nervous system, Autism spectrum disorder and 4 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 64 submitters), last evaluated 2026-07-20.
ClinVar record 1262 NM_024570.4(RNASEH2B):c.529G>A (p.Ala177Thr)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs75184679 is a single position in the genome, in or near the RNASEH2B gene. Published research associates it with rnaseh2a protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
RNASEH2A protein levels (rs75184679). MyGeneLog™. https://www.mygenelog.com/variants/rs75184679