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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 119,110 European ancestry cases, 909,847 European ancestry controls.
The effect
Each copy of the A allele carried 0.96 times the odds of ICD10 M54: Dorsalgia (95% confidence interval 0.95-0.97); p = 1 × 10−15.
How common The A allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 10, band 10q22.1 — in an intron of CHST3.
What each result means
A/ATwo copies of the version the research linked to ICD10 M54: Dorsalgia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to ICD10 M54: Dorsalgia. That is a smaller link than two copies.
G/GNo copy of the version the research linked to ICD10 M54: Dorsalgia. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35110524 · open access
Questions about rs751450
What is rs751450?
rs751450 is a single position in the genome, in or near the CHST3 gene. Published research associates it with icd10 m54: dorsalgia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs751450 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs751450 come from?
GWAS Catalog, Nature communications 2022, PMID:35110524. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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