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Psoriasis

SYNGAP1 · rs75086869

Where this position leads

Condition: Psoriasis

rs75086869 Condition: Psoriasis Psoriasis Condition rs75086869 rs75086869 SYNGAP1

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.262 higher (95% confidence interval 0.19-0.33); p = 2 × 10−27.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of SYNGAP1.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source

Questions about rs75086869

What is rs75086869?

rs75086869 is a single position in the genome, in or near the SYNGAP1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75086869 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs75086869 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75086869 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Psoriasis (rs75086869). MyGeneLog™. https://www.mygenelog.com/variants/rs75086869

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