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Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.119 lower (95% confidence interval 0.055-0.183); p = 4 × 10−10.
Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.
What each result means
C/CNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of translational medicine · 2025 · PMID 39885523 · open access
Questions about rs75029704
What is rs75029704?
rs75029704 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs75029704 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs75029704 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs75029704 come from?
GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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