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Who was studied 34,541 cases, 261,984 controls; replicated in 88,192 cases, 162,544 controls.
The effect
Each copy of the A allele shifted the measure 0.043 higher (95% confidence interval 0.031-0.055); p = 1 × 10−12.
How common The A allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 17, band 17q21.33 — in an intron of ZNF652-AS1.
What each result means
A/ATwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Circulation research · 2018 · PMID 29212778 · open access
Questions about rs7502499
What is rs7502499?
rs7502499 is a single position in the genome, in or near the PHB gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7502499 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7502499 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7502499 come from?
GWAS Catalog, Circulation research 2018, PMID:29212778. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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