Urinary 3-hydroxyisovalerate to urinary creatinine ratio
ACSM2B · rs7499358
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,007 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.62 lower (95% confidence interval 0.5-0.74); p = 8 × 10−22.
How common The A allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 16, band 16p12.3 — in an intron of ACSM2B.
What each result means
A/ATwo copies of the version the research linked to Urinary 3-hydroxyisovalerate to urinary creatinine ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Urinary 3-hydroxyisovalerate to urinary creatinine ratio. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Urinary 3-hydroxyisovalerate to urinary creatinine ratio. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 39746953 · open access
Questions about rs7499358
What is rs7499358?
rs7499358 is a single position in the genome, in or near the ACSM2B gene. Published research associates it with urinary 3-hydroxyisovalerate to urinary creatinine ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7499358 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7499358 come from?
GWAS Catalog, Nature communications 2025, PMID:39746953. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Urinary 3-hydroxyisovalerate to urinary creatinine ratio (rs7499358). MyGeneLog™. https://www.mygenelog.com/variants/rs7499358