GAS8 · rs7498985
Where this position leads
Condition: Basal Cell Carcinoma
What the study found
Who was studied 20,791 European ancestry cases, 286,893 European ancestry controls; replicated in 251,963 European ancestry cases, 2,271,667 European ancestry controls.
The effect The reported allele is A; the catalogue records no effect size ; p = 5 × 10−97.
Where it sits Chromosome 16, band 16q24.3 — in an intron of GAS8.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-11.
ClinVar record 1272080 NM_001481.3(DRC4):c.756+123G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs7498985 is a single position in the genome, in or near the GAS8 gene. Published research associates it with basal cell carcinoma (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2022, PMID:36496446. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Basal cell carcinoma (MTAG) (rs7498985). MyGeneLog™. https://www.mygenelog.com/variants/rs7498985