IFNA6 · rs74912790
Where this position leads
Condition: Epilepsy
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 34 Korean ancestry cases, 1,080 Korean ancestry healthy controls.
The effect Each copy of the A allele carried 10.70 times the odds of Epilepsy and lamotrigine-induced maculopapular eruptions; p = 1 × 10−9.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 9, band 9p21.3 — between genes, 3.1 kb from IFNA6.
rs74912790 is a single position in the genome, in or near the IFNA6 gene. Published research associates it with epilepsy and lamotrigine-induced maculopapular eruptions. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Epilepsy. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Epilepsy research 2015, PMID:26220383. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Epilepsy and lamotrigine-induced maculopapular eruptions (rs74912790). MyGeneLog™. https://www.mygenelog.com/variants/rs74912790