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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 14,764 European ancestry cases, 2,091,602 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 1.09 higher (95% confidence interval 0.71-1.47); p = 1 × 10−8.
How common The C allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — in an intron of SHD.
What each result means
C/CTwo copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs748832306
What is rs748832306?
rs748832306 is a single position in the genome, in or near the SHD gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs748832306 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs748832306 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs748832306 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 413Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others3Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs748832306). MyGeneLog™. https://www.mygenelog.com/variants/rs748832306