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Thyroid peroxidase antibody positivity in pregnancy

near GPR89P · rs74868707

What the study found

Who was studied 10,218 Chinese ancestry cases, 58,843 Chinese ancestry controls.

The effect Each copy of the G allele carried 1.57 times the odds of Thyroid peroxidase antibody positivity in pregnancy (95% confidence interval 1.39-1.76); p = 5 × 10−14.

How common The G allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 9.5 kb from GPR89P.

What each result means

A/A No copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs74868707

What is rs74868707?

rs74868707 is a single position in the genome, in or near the near GPR89P gene. Published research associates it with thyroid peroxidase antibody positivity in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs74868707 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74868707 come from?

GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid peroxidase antibody positivity in pregnancy (rs74868707). MyGeneLog™. https://www.mygenelog.com/variants/rs74868707

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