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Who was studied 22,525 European ancestry cases, 638,618 European ancestry controls.
The effect
Each copy of the T allele carried 0.82 times the odds of Surgical knee osteoarthritis (95% confidence interval 0.77-0.88); p = 3 × 10−9.
How common The T allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 2, band 2q31.1 — between genes, 1 kb from DAP3P2.
What each result means
C/CNo copy of the version the research linked to Surgical knee osteoarthritis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Surgical knee osteoarthritis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Surgical knee osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Annals of the rheumatic diseases · 2023 · PMID 36376028
Questions about rs74860745
What is rs74860745?
rs74860745 is a single position in the genome, in or near the near DAP3P2 gene. Published research associates it with surgical knee osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74860745 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs74860745 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74860745 come from?
GWAS Catalog, Annals of the rheumatic diseases 2023, PMID:36376028. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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