TACR3 · rs74827081
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 68,916 European ancestry post-menopausal cases, 67,433 European ancestry post-menopausal controls, 5,421 African ancestry post-menopausal cases, 2,668 African ancestry post-menopausal controls, 1,889 Hispanic post-menopausal cases, 889 Hispanic post-menopausal controls, 146 East Asian ancestry post-menopausal cases, 485 East Asian ancestry post-menopausal controls, 409 South Asian ancestry post-menopausal cases, 1,304 South Asian ancestry post-menopausal controls.
The effect Each copy of the G allele carried 1.27 times the odds of Hot flashes or menopausal hormone therapy (95% confidence interval 1.23-1.32); p = 7 × 10−41.
Where it sits Chromosome 4, band 4q24 — in an intron of TACR3.
rs74827081 is a single position in the genome, in or near the TACR3 gene. Published research associates it with hot flashes or menopausal hormone therapy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications medicine 2026, PMID:41495267. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hot flashes or menopausal hormone therapy (rs74827081). MyGeneLog™. https://www.mygenelog.com/variants/rs74827081