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Who was studied 93,263 European ancestry cases, 532,679 European ancestry controls, 2,748 African ancestry cases, 5,222 African ancestry controls, 3,962 East Asian ancestry cases, 4,074 East Asian ancestry controls, 1,088 Hispanic or Latin American cases, 1,152 Hispanic or Latin American controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−10.
Where it sits Chromosome 14, band 14q22.1 — in an intron of FERMT2.
What each result means
C/CNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2023 · PMID 37198259 · open access
Questions about rs74825460
What is rs74825460?
rs74825460 is a single position in the genome, in or near the FERMT2 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74825460 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does having rs74825460 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74825460 come from?
GWAS Catalog, Molecular psychiatry 2023, PMID:37198259. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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