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Psoriasis

TNIP1 · rs74817271

Where this position leads

Condition: Psoriasis

rs74817271 Condition: Psoriasis Psoriasis Condition rs74817271 rs74817271 TNIP1

What the study found

Who was studied 20,105 European ancestry cases, 842,975 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.263 higher (95% confidence interval 0.21-0.32); p = 7 × 10−23.

How common The A allele had a frequency of about 93% in the people studied.

Where it sits Chromosome 5, band 5q33.1 — inside TNIP1.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization
Liu S, Li L, Liang Y, Tan Y, Wang X, Feng Y, Chen N, Lei X
Briefings in bioinformatics · 2024 · PMID 39883516 · open access

Questions about rs74817271

What is rs74817271?

rs74817271 is a single position in the genome, in or near the TNIP1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74817271 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs74817271 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74817271 come from?

GWAS Catalog, Briefings in bioinformatics 2024, PMID:39883516. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs74817271). MyGeneLog™. https://www.mygenelog.com/variants/rs74817271

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