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Medication use (antimigraine preparations)

U4 · rs74809038

Where this position leads

What the study found

Who was studied 5,521 European ancestry cases, 114,323 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.158 higher (95% confidence interval 0.11-0.21); p = 4 × 10⁻⁹.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 6, band 6q22.31 — between genes, 32.9 kb from RNU4-35P.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Medication use (antimigraine preparations) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (antimigraine preparations).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (antimigraine preparations) compared to the general population.

Source

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu Y, Byrne EM, Zheng Z, Kemper KE, Yengo L, Mallett AJ, Yang J, Visscher PM, Wray NR

Nature communications · 2019 · PMID 31015401 · open access

Questions about rs74809038

What is rs74809038?

rs74809038 is a single position in the genome, in or near the U4 gene. Published research associates it with medication use (antimigraine preparations). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74809038 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs74809038 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74809038 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Medication use (antimigraine preparations) (rs74809038). MyGeneLog™. https://www.mygenelog.com/variants/rs74809038

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