Sensitive

Response to lithium treatment in bipolar disorder (continuous phenotype)

AL157359.3 · rs74795342

Where this position leads

What the study found

Who was studied 2,039 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 1.16 higher (95% confidence interval 0.78-1.54); p = 3 × 10⁻⁹.

How common The G allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 21, band 21q21.1 — between genes, 95.7 kb from PPIAP22.

What each result means

A/A No copy of the version the research linked to Response to lithium treatment in bipolar disorder (continuous phenotype). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Response to lithium treatment in bipolar disorder (continuous phenotype). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Response to lithium treatment in bipolar disorder (continuous phenotype). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S

and 111 more — show all

Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG

Lancet (London, England) · 2016 · PMID 26806518 · open access

Questions about rs74795342

What is rs74795342?

rs74795342 is a single position in the genome, in or near the AL157359.3 gene. Published research associates it with response to lithium treatment in bipolar disorder (continuous phenotype). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74795342 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs74795342 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74795342 come from?

GWAS Catalog, Lancet (London, England) 2016, PMID:26806518. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Response to lithium treatment in bipolar disorder (continuous phenotype) (rs74795342). MyGeneLog™. https://www.mygenelog.com/variants/rs74795342

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