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Who was studied 24,009 European ancestry cases, 150,983 European ancestry controls, 5,373 African ancestry cases, 42,485 African ancestry controls, 1,925 Hispanic cases, 18,285 Hispanic controls; replicated in 5,117 European ancestry cases, 389,291 European ancestry controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Peripheral artery disease (95% confidence interval 1.04-1.08); p = 8 × 10−10.
How common The C allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 11, band 11p11.2 — in the 3′ untranslated region of CREB3L1.
What each result means
A/ANo copy of the version the research linked to Peripheral artery disease. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Peripheral artery disease. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Peripheral artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature medicine · 2019 · PMID 31285632 · open access
Questions about rs7476
What is rs7476?
rs7476 is a single position in the genome, in or near the CREB3L1 gene. Published research associates it with peripheral artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7476 linked to?
On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7476 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7476 come from?
GWAS Catalog, Nature medicine 2019, PMID:31285632. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 152328Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others8Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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