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Insulin-like growth factor 1 levels

near RPL26P28 · rs7475343

Where this position leads

Condition: Gout

rs7475343 Condition: Gout Gout Condition rs7475343 rs7475343 near RPL26P28

What the study found

Who was studied 340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0347 higher (95% confidence interval 0.029-0.041); p = 3 × 10−30.

Where it sits Chromosome 10, band 10p15.1 — between genes, 3 kb from RPL26P28.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Insulin-like growth factor 1 levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Insulin-like growth factor 1 levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Insulin-like growth factor 1 levels compared to the general population.
Source

Questions about rs7475343

What is rs7475343?

rs7475343 is a single position in the genome, in or near the near RPL26P28 gene. Published research associates it with insulin-like growth factor 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7475343 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs7475343 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7475343 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Insulin-like growth factor 1 levels (rs7475343). MyGeneLog™. https://www.mygenelog.com/variants/rs7475343

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