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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 13,552 European, African American or Afro-Caribbean, Hispanic or Latin American, Asian, Native American, Other ancestry individuals.
The effect
Each copy of the G allele shifted the measure 3.84 kg higher; p = 6 × 10−9.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 2, band 2q33.1 — in an intron of PLCL1.
What each result means
A/ANo copy of the version the research linked to Hand grip strength. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Hand grip strength. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Hand grip strength. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs74688411 is a single position in the genome, in or near the PLCL1 gene. Published research associates it with hand grip strength. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs74688411 linked to?
On MyGeneLog this position is linked to Hand Grip Strength. The research behind each link, and its sources, are set out on that condition page.
Does having rs74688411 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs74688411 come from?
GWAS Catalog, PloS one 2021, PMID:34214102. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hand grip strength (rs74688411). MyGeneLog™. https://www.mygenelog.com/variants/rs74688411